1. Set goals and know understand the objective of your web design
What is it trying to achieve?
Wow the audiences?
Design a simple web user interface?
2. Design Consistency
Many web pages has more than 10 types of fonts with 20 types of sizes. Ever seen this type of web design?
Use CSS to help maintain a consistency through out your web design.
3. Font Type
Use readable font for your audiences. After all, you are trying to let your audiences understand about this web site that you have designed.
4. Important information at the top of the page
While if important words are positioned at the top of web pages, it helps in SEO, this is not the main factor. You want to convey your message immediately when the page loads.
Make sure your links is clearly visible. Do not use the same text and font and color for links.